Sickle cell disease (SCD) remains one of the most common inherited disorders on the globe. Since its inception, blood transfusion remains pivotal therapy in the management of such patients. Before…
Following receipt of an email from The NEJM, about the notable articles of 2019, one paper stood out for me - this involved the clinical phase 3 trial of voxelotor…
We’ve enjoyed three articles about hydroxyurea so far. Let’s summarize the recommendations for the administration of hydroxyurea alias Hydroxycarbamide. These are; Educate all patients with SCA and their family members…
No drug is safe to administer to any patient, not even vitamin supplements. And because hydroxyurea is an anticancer per se, documentation that includes, but not limited to informed consent…
If you’ve read the previous article about the vital facts about hydroxyurea in sickle cell disease, you now have an idea about the drug. There are features that any therapeutic…
It is not very common that a drug like hydroxyurea is so exceptionally incredible, yet it has not gained as much traction and attention as it should have. It may…
Hepatobiliary complications in sickle cell disease range from gallbladder stones to life-threatening acute hepatic sequestration. For simplicity, we classify them as biliary and hepatic complications. Complications of the biliary tract…
Stuttering priapism - no one has ever wanted surprising erections - so every effort must be made to prevent them, by keeping the body hydrated. Stuttering or recurrent priapism is…
Avascular necrosis (AVN) is one of the most common causes of chronic pain in sickle cell disease. We define it as bone death due to compromised blood supply. The hip…
Pulmonary hypertension is one of those chronic complications of sickle cell disease that you only hear on ward rounds or clinic visits headed by senior clinicians. The diagnostic criterion is…