Buruli ulcer, a neglected tropical disease, is a debilitating condition that primarily affects impoverished communities in certain regions of the world.

Unveiling Buruli Ulcer: Understanding a Neglected Tropical Disease


Buruli ulcer, a neglected tropical disease, is a debilitating condition that primarily affects impoverished communities in certain regions of the world. Despite its significant impact on individuals and communities, this disease remains unknown. In this scientific article, we shed light on Buruli ulcer, exploring its causes, symptoms, transmission, and available treatment options, while emphasizing the importance of awareness and early detection.

Understanding Buruli Ulcer

Buruli ulcer is a chronic infectious disease caused by the bacterium Mycobacterium ulcerans. It primarily affects the skin and, in severe cases, can cause extensive tissue damage. The disease is prevalent in rural areas of tropical and subtropical regions, particularly in West and Central Africa, as well as some parts of Australia and South America.


The exact mode of transmission of Buruli ulcer is still not fully understood. However, it is believed to occur through contact with contaminated environments such as stagnant or slow-moving water bodies, wetlands, and tropical forests. The bacteria may enter the body through cuts, wounds, or insect bites. Poor hygiene practices, inadequate wound care, and limited access to clean water and sanitation facilities contribute to the risk of infection.

Symptoms and Progression

Buruli ulcer typically begins as painless, small nodules or swellings on the skin. Over time, these nodules can develop into large ulcers with undermined edges. The ulcers may be accompanied by other symptoms, including swelling, redness, and occasionally, the formation of a necrotic or “black” area in the affected skin. In advanced cases, the ulcers can cause severe deformities and disabilities.

Treatment and Prevention of Buruli ulcer

Early diagnosis and treatment are crucial for Buruli ulcer management. The disease can be treated with a combination of antibiotics, usually administered over a prolonged period. The antibiotics target the bacteria, reducing the extent of tissue damage and promoting healing. In some cases, surgical intervention may be necessary to remove dead tissue or repair deformities.

Prevention strategies include:

  1. Raising Awareness: Educating communities, healthcare providers, and policymakers about Buruli ulcers is essential. This can help promote early recognition of symptoms, prompt treatment-seeking behaviour, and the implementation of preventive measures.
  2. Wound Care and Hygiene: Promptly cleaning and covering cuts, wounds, and insect bites with clean dressings can reduce the risk of infection. Good hygiene practices, such as regular handwashing and proper wound care, are crucial in preventing the spread of the bacteria.
  3. Environmental Management: Efforts to minimize human contact with potentially contaminated environments, such as improving water and sanitation infrastructure, reducing human-wildlife interactions, and implementing appropriate land-use practices, can help reduce the risk of Buruli ulcer transmission.
  4. Early Detection and Access to Healthcare: Strengthening healthcare systems in endemic areas, ensuring access to diagnostic facilities, and training healthcare providers in the early recognition and management of Buruli ulcers are vital steps in combating the disease.


Buruli ulcer is a neglected tropical disease that affects vulnerable communities, causing significant morbidity and long-term disabilities. By increasing awareness, promoting early detection, and implementing effective prevention and treatment strategies, we can make progress in reducing the burden of this disease. Through collaborative efforts between communities, healthcare providers, researchers, and policymakers, we can work towards eliminating Buruli ulcers and improving the health and well-being of affected individuals.

Visit WHO for more information.

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